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Making Sense of Your Pathology Report


Knowledge image

A pathology report is a medical document written by a pathologist, a doctor who special­izes in interpreting laboratory tests and evaluating cells, tissues, and organs to diagnose disease. The report specifies a diagnosis based on the pathologist’s examination of a sample of tissue taken from a tumor. This tissue sample, or specimen, is obtained through a biopsy.

The pathologist’s examination reveals whether the tumor tissue from the biopsy is benign (noncancerous) or malignant (cancerous, meaning it can spread to other parts of the body). If it is cancerous, the pathologist may perform additional tests on the sample to learn more about the cancer. Your doctor will receive these test results as they become available, so it may take a few days to a few weeks to receive the full report, depending on the studies the pathologist performs.

The pathology report provides specific information about the charac­teristics of the tumor, which helps your doctor determine the best cancer treatment options to recommend for you. The report contains highly technical medical terms because it is a communication between two doctors – the pathologist and the oncologist. However, you are entitled by law to receive a copy, and you can understand it with the help of your healthcare team. Ask your doctor to explain the pathol­ogy report results and what they mean. You may also speak directly with the pathologist for an explanation of the findings listed in the report.

Ask your doctor to explain the pathology report results and what they mean.

Parts of a Pathology Report
Different pathologists use different words to describe the same things. However, most pathology reports include the following elements:

♦ Patient, doctor, and specimen identification This section lists your name, birth date, and other personal information; the pathologist’s and oncologist’s contact information; and details about the specimen, including the type of biopsy or surgery performed and the type of tissue obtained.

♦ Gross (obvious) description This section describes the tissue sample (or tumor, if it was removed) as seen with the naked eye, including the gen­eral color, weight, size, and consistency.

♦ Microscopic description This highly technical section, which serves as the basis for the diagnosis section, describes what the cancer cells look like when viewed under a microscope. The micro­scopic part of the report also specifies the type of cancer.

In each organ, many different types of tumors can develop, each with a varying ability to spread to other organs. Tumors of many types may be classified as noninvasive (in situ) or invasive. Invasive tumors have the ability to metastasize, or spread to other parts of the body. Although noninvasive tumors do not metastasize, they can develop into or raise a person’s risk of a more serious, invasive tumor in the future. For invasive tumors, it’s important for the pathologist to note how far the tumor has invaded into the wall or surrounding healthy tissues of the organ where it started, if that organ was examined.

Another important characteristic of each tumor is the histologic grade , which describes how the cancer cells look compared with healthy cells. In general, the pathologist is looking for differences in the size, shape, and stain­ing characteristics of the cells. A tumor with cells that look more like healthy cells is called low grade or well differentiated , while a tumor with cells that look less like healthy cells is called high grade, poorly differentiated , or undifferentiated . In most situations, the prognosis (chance of recovery) is better for a person who has a tumor with cells that look more like healthy cells. There are different methods used to assign a cancer grade for different types of cancers.

In addition, the pathologist usually will comment on how often he or she sees cells that are dividing, also known as the mitotic rate. Tumors with fewer dividing cells typically are low grade and are more likely to correspond to a better prognosis.

Another important factor is whether cancer cells can be found at the margins (edges) of the biopsy. If tumor cells are present, the margins are described as positive or involved . This result suggests that cancerous cells may have been left behind in the body and may indicate the need for additional surgery to completely remove the tumor.

The pathologist will also document whether the cancer has spread to nearby lymph nodes or other organs. Lymph nodes that contain cancer are said to be positive , while those that do not are described as negative . If the tumor has invaded the blood vessels or lymph vessels that flow into the lymph nodes, the likelihood of distant spread may be greater. The pathologist will specifically comment on these findings in the report if they are observed.

Combining the tumor size, location, and spread enables the pathologist to assign a stage to the cancer, typically using the TNM system from the Ameri­can Joint Committee on Cancer. This system examines three factors: the size and location of the tumor (tumor, T), whether cancer cells have spread to the lymph nodes located near the tumor (node, N), and whether the tumor has spread to other parts of the body (metastasis, M). The pathologic stage, along with the results of other diagnos­tic tests, helps determine the clinical stage of the cancer, which usually helps guide a person’s treatment options.

In many cases, the pathologist per­forms special tests to identify specific genes, proteins, and other factors that further characterize the tumor. The results of these tests may be listed in a separate section or in a separate report. These additional tests are especially important for diagnosis because choos­ing the best treatment option may depend on these results.

♦ Diagnosis This section provides the “bottom line” and may be found at either the beginning or the end of the report. If cancer has been diagnosed, the section may include the type of cancer (such as carcinoma or sarcoma), tumor grade, lymph node status, margin status, and stage. In addition, it will list any specialized test results, which could indicate the presence of hormone receptors or other tumor markers.

Sampling Differences
In some cases, the pathology report for an initial biopsy may differ from a later report that evaluates the entire tumor after it has been removed. This happens because the characteristics of a tumor can sometimes vary in different areas. Your doctor will consider all of the reports to develop a treatment plan that best addresses your particular situation.

Getting a Second Opinion
It may be valuable to seek the knowledge and advice of more than one doctor regarding your diagnosis and treatment plan, which is based on the pathology report and the results of other diagnostic tests. This is called a second opinion. If you choose to get a second opinion, it is important to get a copy of the pathology report and any other medical records to share with the second doctor, but be aware that doctors work closely with their own pathologists and may prefer to have their pathologist’s opinion in addition to the original pathology report. Additional tests can be performed on the biopsy if they are necessary or if the results of the original report are in question. The tissue specimen is kept for a long time and is available upon request.

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Reprinted with permission from Cancer.Net. © 2013 American Society of Clinical Oncology. All rights reserved.

This article was published in Coping® with Cancer magazine, May/June 2013.